Neurobiology of Disease Induction of Brain Region-Specific Forms of Obesity by Agouti
نویسندگان
چکیده
Martien J. H. Kas,1 Birgitte Tiesjema,1 Gertjan van Dijk,2 Keith M. Garner,1 Gregory S. Barsh,3 Olivier Ter Brake,4 Joost Verhaagen,4 and Roger A. H. Adan1 1Rudolf Magnus Institute of Neuroscience, Department of Pharmacology and Anatomy, University Medical Centre Utrecht, 3584 CG Utrecht, The Netherlands, 2Division of Neuroendocrinology, Department of Animal Physiology, University of Groningen, 9750 AA Haren, The Netherlands, 3Department of Pediatrics and Genetics, Howard Hughes Medical Institute, Stanford University, Stanford, California 94305, and 4Graduate School Neurosciences Amsterdam, Netherlands Institute for Brain Research, 1105 AZ Amsterdam, The Netherlands
منابع مشابه
Induction of brain-region-specific forms of obesity by agouti.
Disruption of melanocortin (MC) signaling, such as by ectopic Agouti overexpression, leads to an obesity syndrome with hyperphagia, obesity, and accelerated body weight gain during high-fat diet. To investigate where in the brain disruption of MC signaling results in obesity, long-term Agouti expression was induced after local injections of recombinant adeno-associated viral particles in select...
متن کاملP104: Obesity-Induced Neuroinflammation: Focus on Hypothalamic Inflammation
Obesity is a Health issue around the world. Obesity is not limited to body weight, generally associated with low grade inflammation and with a cluster of disorders generally referred to as "metabolic syndrome". Regarding obesity and relapse, long-term concentration was set on the hypothalamus. Most recently,obesity- Originated neuroinflammation has been shown to affect other brain str...
متن کاملDifference in transient ischemia-induced neuronal damage and glucose transporter-1 immunoreactivity in the hippocampus between adult and young gerbils
Objective(s): The alteration of glucose transporters is closely related with the pathogenesis of brain edema. We compared neuronal damage/death in the hippocampus between adult and young gerbils following transient cerebral ischemia/reperfusion and changes of glucose transporter-1(GLUT-1)-immunoreactive microvessels in their ischemic hippocampal CA1 region. Materials and Methods: Transient cere...
متن کاملP 24: Evaluation of the Voxel Based Morphometry in Quantitative Analysis of Brain MRI Images
Introduction: Voxel based morphometry is a type of statistical parametric mapping that can be used to investigate the effect of diseases such as epilepsy, Alzheimer's disease and Parkinson's disease or other agent such as skills on brain structure (white matter, gray matter and cerebrospinal fluid). The aim of this study is evaluate the effectiveness of this method in detection of differen...
متن کاملNew Insights into the Effect of Diabetes and Obesity in Alzheimer’s Disease
Abstract Alzheimer’s disease (AD) is the most common cause of dementia in elderly people. The prevalence of Alzheimer diseases is increasing in the world due to population aging. Metabolic disease such as diabetes and obesity play important role in Alzheimer disease. Hyperglycemia can play important role in brain damage. It causes cognitive impairments, functional and structural alterations in...
متن کامل